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Craving an afternoon snack?

Take a drag on a cigarette, and your hunger will likely disappear. Smoking is the number one cause of preventable deaths in the Unites States and other developed countries, causing lung cancer, heart disease, and chronic bronchitis.

But smokers are, on average, skinnier than nonsmokers. New research reveals how nicotine, the active ingredient in cigarettes, works in the brain to suppress smokers' appetites. The finding also pinpoints a new drug target for nicotine withdrawal—and weight loss.

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The nicotine receptor in the brain has 15 subunits; they can combine in a multitude of ways to form different receptors with Seeking slim slender occasional smoker jobs. Nicotine can bind to each combination and spur a cascade of distinct events; some lead to the addictive properties of cigarettes, others to an increase in blood pressure or a feeling of relaxation.

It's long been known smoer nicotine causes a slump in appetite, and scientists suspected that this zlim through receptors associated with reward and behavior reinforcement.

After all, the brain considers both cigarettes and food to be rewards. But the new finding suggests that appetite has its own pathway.

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It's indistinguishable from the signal the brain propagates after eating a large meal. Since the weight gain that comes with stopping smoking is often one Seekign for smokers to quit, Picciotto suggests that the Seekint pathway could be targeted by pharmaceuticals to suppress appetite during the initial stages of smoking cessation. In addition, such a drug could have wider reach as an appetite suppressant to Seeking slim slender occasional smoker in weight loss, without the health hazards tied to cigarette smoke.

Neil Grunberg, a behavioral neuroscientist at the Uniformed Services University of the Health Sciences in Bethesda, Maryland, oxcasional the first to prove, through rat studies inthat nicotine causes a decrease in appetite. He says the new study is a step forward in understanding the Seeking slim slender occasional smoker he first observed. Grunberg notes, however, that the study looks only at male mice.

In his previous work, he has found differences in the effects of nicotine on weight between males and females. Females, he says, experience larger weight loss when they start smoking and a larger weight gain if they quit.

Whether this means nicotine is working through an additional, hormone-regulated pathway in the female brain is yet to be determined. Picciotto says her group is repeating the experiments on female mice. By Jocelyn Kaiser Mar.

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